\u00ab\u00a0En raison de ces nouvelles donn\u00e9es, compte tenu du caract\u00e8re non indispensable de ces sirops et de l\u2019existence d\u2019alternatives th\u00e9rapeutiques, nous estimons que leur rapport b\u00e9n\u00e9fice \/ risque est d\u00e9favorable. En cons\u00e9quence, nous envisageons de suspendre leurs AMM et d\u2019effectuer un rappel de l\u2019ensemble de ces sirops d\u00e9but septembre.\u00a0\u00bb<\/em> poursuit l’ANSM.\u00a0<\/span><\/p>\nLes sirops \u00e0 base de pholcodine sont utilis\u00e9s pour calmer les toux s\u00e8ches et les toux d’irritation chez les adultes et les enfants de plus de 30 mois et de plus de 15 kg. En France, ils ne peuvent \u00eatre d\u00e9livr\u00e9s que sur ordonnance depuis 2011.<\/p>\n
Plusieurs avertissements sur les risques<\/h3>\n
En avril 2020, lors de l\u2019\u00e9pid\u00e9mie de Covid-19, le risque de r\u00e9action allergique grave li\u00e9e \u00e0 la pholcodine avait amen\u00e9 l\u2019ANSM \u00e0 recommander de ne pas utiliser ces sirops contre la toux.<\/p>\n
En janvier 2022, le comit\u00e9 de pharmacovigilance de l\u2019agence europ\u00e9enne du m\u00e9dicament (EMA) a recommand\u00e9 de mettre \u00e0 jour les r\u00e9sum\u00e9s des caract\u00e9ristiques du produit et les notices des m\u00e9dicaments \u00e0 base de pholcodine pour inclure un avertissement sur le risque de surconsommation et de r\u00e9action crois\u00e9e avec les curares, sur la base notamment de nouvelles donn\u00e9es.<\/p>\n
Quels sont les sirops concern\u00e9s?<\/h3>\n
Les sirops concern\u00e9s par cette mise en garde de l\u2019ANSM sont :\u00a0le Dim\u00e9tane sans sucre 133 mg\/100 ml, sirop (Biocodex) ; le Biocalyptol 6,55 mg\/5 ml sans sucre, sirop \u00e9dulcor\u00e9 \u00e0 la saccharine sodique et au maltitol liquide (Zambon) ; le Biocalyptol, sirop (Zambon) et le Pholcodine Biogaran 6,55 mg\/5 ml, sirop (Biogaran)<\/strong>.<\/p>\nPour les patients qui utilisent ou ont d\u00e9j\u00e0 utilis\u00e9 un sirop antitussif contenant de la pholcodine,\u00a0\u00ab <\/strong>il n\u2019y a pas de surveillance particuli\u00e8re recommand\u00e9e \u00e0 l\u2019heure actuelle<\/em> \u00bb,<\/strong>\u00a0selon l\u2019ANSM.<\/p>\nSi toutefois vous \u00eates amen\u00e9 \u00e0 subir une anesth\u00e9sie g\u00e9n\u00e9rale, le m\u00e9decin anesth\u00e9siste pourra vous demander si vous avez d\u00e9j\u00e0 consomm\u00e9 ce type de sirop. Pensez \u00e0 l\u2019en informer directement s’il ne vous interroge pas lui-m\u00eame sur ce point.<\/p>\n
L\u2019ANSM appelle les anesth\u00e9sistes-r\u00e9animateurs \u00e0 demander aux patients s\u2019ils ont d\u00e9j\u00e0 consomm\u00e9 ce type de sirop, et aux m\u00e9decins et pharmaciens \u00e0 expliquer le risque de r\u00e9action crois\u00e9e aux curares en cas d\u2019anesth\u00e9sie g\u00e9n\u00e9rale aux patients en ayant d\u00e9j\u00e0 pris.<\/p>\n
Renseignements :\u00a0https:\/\/ansm.sante.fr\/actualites\/risque-dallergie-grave-aux-curares-en-cas-dutilisation-des-sirops-contre-la-toux-contenant-de-la-pholcodine<\/a><\/strong><\/p>\nC.K.N.<\/p>\n","protected":false},"excerpt":{"rendered":"
L\u2019Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament (ANSM) a publi\u00e9 le 1er septembre une mise en garde concernant certains sirops pour […]<\/p>\n","protected":false},"author":52,"featured_media":13365,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,14,5],"tags":[4244,4245,85,4246,4247,4248],"acf":[],"yoast_head":"\n
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![\"pharmacie-2\"](\"\/2019\/10\/pharmacie-2.jpg\")
<\/a>L\u2019Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament (ANSM) <\/a>a publi\u00e9 le 1er septembre une mise en garde concernant certains sirops pour la toux.\u00a0La pholcodine utilis\u00e9e dans ces m\u00e9dicaments risque de provoquer une allergie grave aux curares lors d’anesth\u00e9sies.<\/span><\/h2>\n